NCT01051583

Avastin as an Adjunct to Diode Laser in the Treatment of Neovascular Glaucoma

Avastin as an Adjunct to Diode Laser Cyclophotoablation in the Treatment of Neovascular Glaucoma

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 14 Years – 72 Years
• Healthy volunteers: Not accepted

Summary

Assess the efficacy of Avastin as an adjunct to Diode Laser cyclophotocoagulation in the treatment of Neovascular Glaucoma.

Detailed description

Design: Prospective, comparative interventional case series. Method: Patients were randomly assigned into Group A which were treated with Diode laser cyclophotocoagulation alone, whereas group B received intravitreal Avastin (One milligram = 0.04mL of 25 mg/mL) in conjunction with the Diode Laser. The preoperative data included etiology, mean age; follow up period, and a full ophthalmological examination with emphasis on mean IOP, iris neovascularization, pain and corneal edema.

Conditions

• Neovascular Glaucoma

Interventions

Type	Name	Description
PROCEDURE	Diode laser cyclophotocoagulation enhanced by intravitreal injection of Avastin	The operative procedure involved retro-bulbar anesthesia, draping the patient in an aseptic manner, introduction of an eye speculum, 30 laser shots over 270 degrees of the circumference of the limbus. For our study we used the Iris Diode laser machine, the G-probe and we adjusted the settings for 2500 millisecond duration and the 3000 milli-joule and reduced the power progressively until just below the energy level that produced a pop.then after applying the laser, we performed a paracentesis with a 27 gauge needle to soften the globe, followed by intravitreal injection of the Avastin from a site 3.5 millimeter posterior to the limbus. The dose we administered was one milligram of bevacizumab (0.04 mL of 25 mg/mL).

Timeline

• Start date: 2006-01-01
• Primary completion: 2008-04-01
• Completion: 2008-04-01
• First posted: 2010-01-18
• Last updated: 2010-01-18

Locations

1 site across 1 country: Egypt