Trials / Unknown
UnknownNCT01050920
Study of Genetic Factors Other Than CYP2C9 and VKORC1 That Influence Warfarin Dose Requirements in a South-east Asian Population
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- —
- Sponsor
- National University Hospital, Singapore · Academic / Other
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Not accepted
Summary
Warfarin is a commonly used anti-coagulant, but has a narrow therapeutic index and wide inter-individual and inter-ethnic variation in dose requirements. Several genetic and non-genetic factors have been identified that could influence warfarin dose requirements. However, current known predictive factors could only explain about 50-60% of warfarin dose variability. Inter-ethnic differences in genetic influences on warfarin dose requirements also exist. We hypothesize that genetic factors other than CYP2C9 and VKORC1 may influence warfarin dosing and serve to further optimize warfarin dosing.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Blood collection |
Timeline
- Start date
- 2013-09-01
- Primary completion
- 2014-12-01
- Completion
- 2014-12-01
- First posted
- 2010-01-18
- Last updated
- 2014-01-22
Locations
1 site across 1 country: Singapore
Source: ClinicalTrials.gov record NCT01050920. Inclusion in this directory is not an endorsement.