NCT01050439

Unrelated Donor Transplant for Malignant and Non-Malignant Disorders

Unrelated Donor Stem Cell Transplant for Patients With Malignant and Non-Malignant Disorders

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Columbia University · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Not accepted

Summary

Unrelated matched donor (cord blood, bone marrow or peripheral blood) allogeneic stem cell transplantation (UDAlloSCT) with either myeloablative or reduced intensity conditioning will be well tolerated and result in a high degree of engraftment in patients with selected malignant and non malignant disorders.

Detailed description

This is a non-randomized study to determine the tolerability and degree of engraftment of unrelated matched donor allogeneic stem cell transplantation with either myeloablative or reduced intensity conditioning in patients with selected malignant and non malignant disorders. Patients will receive one of either full intensity or reduced intensity regimen based on the patient's disease status, organ function and performance and determined by the PI.

Conditions

• Leukemia
• Lymphoma
• Bone Marrow Failure Syndromes
• Immunodeficiencies
• Histiocytosis

Interventions

Type	Name	Description
PROCEDURE	UDAlloSCT	unrelated matched donor allogeneic stem cell transplantation (UDAlloSCT)
OTHER	Therapy	Full Intensity Therapy (myeloablative) (TBI + Thiotepa + Cyc) OR Reduced Intensity Therapy (Fludarabine, Busulfan, and Alemutuzumab (FBA))

Timeline

• Start date: 2002-11-01
• Primary completion: 2011-04-01
• Completion: 2011-04-01
• First posted: 2010-01-15
• Last updated: 2015-04-15

Locations

1 site across 1 country: United States