NCT01049646

Interaction of Apelin and Angiotensin in the Systemic Circulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: Male
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.

Conditions

• Renin Angiotensin System

Interventions

Type	Name	Description
DRUG	Angiotensin II	Infusion of a subpressor dose of angiotensin II will be give, this will be 0.5microG/min/kg. Thereafter thre ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.
DRUG	Saline	Infusion of saline. Thereafter three ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2010-01-14
• Last updated: 2010-08-10

Locations

1 site across 1 country: United Kingdom