NCT01047943

STA-21 Topical Efficacy on Psoriasis

Intrapatient Comparison Study of Efficacy of STA-21 Ointment on Psoriatic Skin Lesions

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Kochi University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The clinical assessment of patients with plaque-type psoriasis is performed by open, intrapatient comparison of 0.2% STA-21 with vehicle(Vaseline) alone within a 2 week period.

Detailed description

Two discrete psoriatic lesions with a similar size (approximately coin-sized) and clinical severity are selected in each patient. Clinical assessment of psoriatic lesion severity is performed at the baseline and at 1 and 2 (end of treatment) using the scores of erythema, induration, scaling on a scale of 0-4 by two observers. Since STA-21 inhibits Stat3 activation, which is essential for disease activity of psoriasis, topical application of 0.2% STA-21 in Vaseline should improve psoriasis in two weeks.

Conditions

• Psoriasis

Interventions

Type	Name	Description
DRUG	Topical application of STA-21 ointment for treatment of psoriasis

Timeline

• Start date: 2007-06-01
• Primary completion: 2008-04-01
• Completion: 2008-04-01
• First posted: 2010-01-13
• Last updated: 2010-01-13

Locations

1 site across 1 country: Japan