NCT01047423

Targeting Microvascular Dysfunction in Young Hypertensive Patients

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Queen's University, Belfast · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Cholesterol and blood pressure lowering tablets have been shown to be of benefit in patients with established high blood pressure. High blood pressure is a very common medical condition that can lead to vascular complications i.e. problems with the blood vessels in the body. One way of detecting early changes in these blood vessels as a result of high blood pressure is to measure their compliance/flexibility with a noninvasive technique known as ultrasound and with a simple blood test. The investigators are trying to establish whether these early changes in blood vessels can be significantly improved by the use of both a cholesterol and blood pressure lowering tablet at an earlier stage than is currently advised. The investigators hope that the early combination of these tablets will prove more effective than the use of a blood pressure lowering tablet by itself and therefore possibly reduce the risk of long term complications developing.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Simvastatin	40mg encapsulated once daily for 12 weeks
DRUG	Placebo	Encapsulated oral once daily for 12 weeks

Timeline

• Start date: 2009-08-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2010-01-12
• Last updated: 2019-07-05

Locations

1 site across 1 country: United Kingdom