NCT01046890

Drug Interactions Between Echinacea Purpurea and Darunavir/Ritonavir

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Germans Trias i Pujol Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this clinical trial is to characterize drug interactions between one medicinal herb widely used by HIV infected patients: Echinacea sp. and the protease inhibitor darunavir/ritonavir.

Detailed description

15 patients on antiretroviral therapy with darunavir/ritonavir 600/100 mg twice a day during four weeks will be recruited. The patients will receive treatment with Echinacea purpurea for 14 days, 500 mg every 6 hours. A 12 hour pharmacokinetic curve will be obtained at baseline and on day 14.

Conditions

• HIV Infections

Interventions

Type	Name	Description
DRUG	Echinacea	darunavir/ritonavir 600/100 mg + root of Echinacea purpurea 500 mg every 6 hours

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-03-01
• Completion: 2010-04-01
• First posted: 2010-01-12
• Last updated: 2019-12-04

Locations

1 site across 1 country: Spain