NCT01045408

The Effect of Berry Extract on Helicobacter Pylori Eradication

The Adjuvant Effect of Berry Extract on Triple Therapy for Helicobacter Pylori Eradication

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Shin Kong Wu Ho-Su Memorial Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer. Helicobacter pylori are found in 70-90% of the population in developing countries and in 25-50% of developed countries.

Detailed description

One-week of triple therapy composed of a proton pump inhibitor plus two antibiotics is currently regarded as the gold standard for HP eradication. However, the eradication rate continues to be disappointing. Poor patient compliance and bacterial resistance are the main factors contributing to treatment failure. Therefore, it is urgently necessary to develop a non-antibiotic alternative therapy to increase the eradication rates of Helicobacter pylori. Some literatures reported that cranberry may inhibit Helicobacter pylori adhesion to the human gastric mucus and may reduce Helicobacter pylori infection in adults. The aims of his experiment were to explore the impact of berry extract on triple therapy for Helicobacter pylori eradication.

Conditions

• Increase the Eradication Rate of Helicobacter Pylori

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Berry extract	Berry extract for weeks

Timeline

• Start date: 2009-01-01
• Primary completion: 2009-12-01
• Completion: 2010-06-01
• First posted: 2010-01-11
• Last updated: 2010-01-14

Locations

1 site across 1 country: Taiwan