NCT01043445

-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.

G Protein-coupled Receptor in the Intestine (GPR 119) Stimulated GLP-1 Secretion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Glostrup University Hospital, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.

Detailed description

We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	GPR 119 agonist, 2-oleyl glycerol	Emulgation, 50 ml. containing 2g 2OG
DIETARY_SUPPLEMENT	Oleic acid	Emulgation, 50 ml. containing 1.54g of oleic acid
DIETARY_SUPPLEMENT	Vehicle	Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol

Timeline

• Start date: 2009-09-01
• Primary completion: 2010-03-01
• Completion: 2010-04-01
• First posted: 2010-01-06
• Last updated: 2014-10-09

Locations

1 site across 1 country: Denmark