NCT01037621

Herpes Simplex Type 2 Co-infection in Veterans With Chronic Hepatitis C

The Interaction of HSV-2 Co-infection in Veterans With Chronic Hepatitis C: the Effect of Valacyclovir on HCV Viral Load

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: G.V. (Sonny) Montgomery VA Medical Center · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This trial is to determine the safety of valacyclovir in persons with chronic hepatitis C and herpes simplex type 2 infection. Participants will be randomized to valacyclovir or matching placebo. After receiving the initial therapy for eight weeks, the participants will cross over to the alternate therapy for an additional eight weeks. Each treatment period will be separated by a two-week period of daily placebo. The hypothesis is that treatment with valacyclovir will result in a significant reduction in serum levels of hepatitis C virus ribonucleic acid.

Conditions

• Hepatitis C Virus Infection
• Infection
• Herpesvirus 2, Human

Interventions

Type	Name	Description
DRUG	Valacyclovir	Valacyclovir 500 mg, 2 caplets twice daily for eight weeks

Timeline

• Start date: 2010-04-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2009-12-23
• Last updated: 2011-11-07

Locations

1 site across 1 country: United States