NCT01035320

Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is compare the effects of simvastatin+ezetimibe with those of simvastatin alone on platelet activity, platelet-leukocyte interactions and inflammatory variables in diabetic patients with or without impaired renal function.

Detailed description

A detailed study protocol is available.

Conditions

• Diabetes Mellitus
• Impaired Renal Function

Interventions

Type	Name	Description
DRUG	Ezetimibe	After a placebo only run-in period patients (two groups) are treated with simvastatin + ezetimibe and simvastatin + placebo in a cross-over trial. Ezetimibe effects on top of simvastatin will be evaluated as the primary aim; simvastatin effects compared to run-in on placebo will be evaluated as a secondary aim.

Timeline

• Start date: 2006-01-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2009-12-18
• Last updated: 2021-03-01

Locations

1 site across 1 country: Sweden