NCT01035307

Studying Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia Previously Enrolled on Clinical Trial POG-9421

Genomic and Proteomic Profiling of Childhood AML

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at biomarkers in tissue samples from young patients with acute myeloid leukemia previously enrolled on clinical trial POG-9421.

Detailed description

OBJECTIVES: * To profile basal and potentiated phospho-protein networks (PPPNs) using tissue samples from pediatric patients with de novo acute myeloid leukemia (AML) previously enrolled on clinical trial POG-9421. * To classify AML-based signal transduction mechanisms. * To correlate profiles of basal and PPPNs with specific molecular lesions (e.g., FLT3-ITD, NPM, WT1, c-kit, CEPBα, PASGΔ75, and karyotype) and profiles of gene expression in tumor tissue samples. OUTLINE: Banked tissue samples are collected for laboratory studies, including phospho-protein signaling and gene expression profiling studies.

Conditions

• Leukemia

Interventions

Type	Name	Description
GENETIC	gene expression analysis
GENETIC	microarray analysis
GENETIC	proteomic profiling
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2009-10-01
• Primary completion: 2016-05-01
• First posted: 2009-12-18
• Last updated: 2016-05-18