NCT01030367

Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients

Pilot Study of Organic Nitrates on Endothelial Progenitor Cells and Endothelial Function in Patients With Coronary Artery Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Julius-Maximilians University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.

Detailed description

In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	PETN, ISDN	Oral dosing of organic nitrates PETN 2x 80mg per day ISDN 2x40mg per day

Timeline

• Start date: 2007-01-01
• Primary completion: 2008-11-01
• Completion: 2010-01-01
• First posted: 2009-12-11
• Last updated: 2009-12-11

Locations

1 site across 1 country: Germany