NCT01028105

Incidence and Relationship of Positive Preoperative Methicillin Resistant Staphylococcus Aureus (MRSA) Screens and Post-operative Infections

Evaluation of the Prevalence of Methicillin Resistant Staphylococcus Aureus Colonization in Pre-Surgical Patients and Post-Operative Infection

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 975 (actual)
• Sponsor: Inova Health Care Services · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the prevalence of pre-surgical patients who are MRSA carriers. From an evidence-based practice perspective, findings from this study can be considered in the evaluation of the hospital SOP mandating pre-surgical MRSA screening requirements for patients with scheduled surgeries. The central hypothesis to be addressed in this study is whether the MRSA colonization and subsequent post-operative infection are the equivalent in these populations.

Detailed description

Design and Methods: Subjects in this study of 975 pre-operative, scheduled surgical patients are in one of the three following groups: * Group 1 (N=325): Allocation sample of surgical patients required to be MRSA screened per hospital SOP (including patients having a positive MRSA history, orthopedic surgery, undergoing dialysis, or transfer from another hospital, nursing home, skilled nursing facility, or jail). * Group 2 (N=650): Randomized sample (1:1 ratio) of surgical patients not required to be MRSA screened per hospital SOP, to one of the following two groups: * 2a (N=325): MRSA screening; or * 2b (N=325): No MRSA screening. All subjects were followed for 30 days post-operatively to determine the incidence of post-operative infection. Treatment, diagnostic, and hospitalization data were collected for patients diagnosed with post-operative infection.

Conditions

• Methicillin-resistant Staphylococcus Aureus Infection

Interventions

Type	Name	Description
OTHER	Preoperative MRSA screening	MRSA preoperative screening and post operative infection rate, 30 days post operative

Timeline

• Start date: 2008-02-01
• Primary completion: 2011-01-01
• Completion: 2013-10-01
• First posted: 2009-12-09
• Last updated: 2021-06-08

Locations

2 sites across 1 country: United States