NCT01027221

Low Dose Radiation to Improve T-Cell Infiltration in Pancreatic Cancer

Randomised Phase I/II Trial in Order to Evaluate the Effect of Neoadjuvant Radiation on Tumor Infiltrating T-cells by Neoadjuvant Low-Dose-Radiation Therapy in Primarily Resectable Pancreatic Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: German Cancer Research Center · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

Principal purpose of the study is the determination of an active local external beam radiotherapy dose leading to a maximum number of tumor infiltrating T-cells.

Conditions

• Primarily Resectable Pancreatic Cancer

Interventions

Type	Name	Description
RADIATION	neoadjuvant photon radiation	single fraction, four dimensions (4D) planned, image guided, Radiation at a dose of 0,5 Gy in Intensity modulated radiotherapy (IMRT)-technique 2 days before resection
RADIATION	neoadjuvant photon radiation	single fraction, 4D-planned, image guided, 2 Gy Radiation to the tumor with a safety margin, in IMRT-technique 2 days before resection
RADIATION	neoadjuvant photon radiation	single fraction, 4D-planned, image guided, 5 Gy Radiation to the tumor with a safety margin, in IMRT-technique 2 days before resection

Timeline

• Start date: 2009-11-01
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2009-12-07
• Last updated: 2021-06-10

Locations

2 sites across 1 country: Germany