NCT01026571

Identification of Genetic Causes of Bicuspid Aortic Valve Disease

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 11,000 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 14 Years – 80 Years
• Healthy volunteers: Accepted

Summary

BAVgenetics is a partnership between Investigators at Boston University, Brigham and Women's Hospital, and Massachusetts General Hospital dedicated to discovering the genetic causes of bicuspid aortic valve disease and associated aortic disease.

Detailed description

The Investigators at BAVgenetics are dedicated to discovering the mechanisms of bicuspid aortic valve disease and why individual genetics seem to play such an important role in generation of this disease. If you have, or have had, a bicuspid aortic valve, we seek your help in this effort by volunteering to donate DNA to the BAV Registry, so that this disease can be better understood and therapies for it can be developed. The BAV Registry is comprised of patients who have donated DNA collected from saliva (spit) and have provided us with personal health information that tells us about their bicuspid aortic valve. Individuals in the Registry have signed the consent form, filled out the medical history questionnaire and the authorization form, and provided DNA via our saliva sample kits. We will send you the requisite forms so that you receive the most up-to-date information about the study as older forms may be outdated. We also need paper copies of the forms; therefore, we send all the forms via ground mail along with a pre-paid return envelope for your convenience.

Conditions

• Bicuspid Aortic Valve

Timeline

• Start date: 2009-12-01
• Primary completion: 2029-12-01
• Completion: 2030-12-01
• First posted: 2009-12-04
• Last updated: 2026-04-01

Locations

1 site across 1 country: United States