NCT01025856

Combined Nutritional and Exercise Strategies to Reduce Liver Fat Content in Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Federico II University · Academic / Other
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.

Conditions

• Postprandial Lipids Metabolism
• Type 2 Diabetes

Interventions

Type	Name	Description
OTHER	Rich in MUFA diet -PA	The patients will follow a rich in MUFA diet without a physical activity program.
OTHER	high fiber/low glycemic index diet + pa	patients will follow for two months a high fibre/ low glycemic index diet with a physical activity program.
OTHER	Rich in MUFA diet+PA	Patients will follow for two months a rich in MUFA diet with a physical activity program.
OTHER	High fibre/low glycemic index diet-PA	Patients will follow for two months a high fibre/low glycemic index diet without a physical activity program.

Timeline

• Start date: 2009-09-01
• Primary completion: 2011-09-01
• Completion: 2011-09-01
• First posted: 2009-12-04
• Last updated: 2012-12-05