Trials / Completed
CompletedNCT01021410
Acetaminophen-Protein Adduct Resolution
Serum Acetaminophen-Cysteine (APAP-cys) Adduct Concentrations After 16 Days of Acetaminophen Dosing
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (actual)
- Sponsor
- Denver Health and Hospital Authority · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to better understand the pharmacokinetics of acetaminophen and further clinical interpretations of laboratory results that confirm the presence of acetaminophen-cys adducts. This study will determine how long adducts persist in serum after a therapeutic course of acetaminophen as taken in a previous study (COMIRB 06-1265). Subjects will be asked to complete three study visits, each three days apart, following termination of COMIRB 06-1265. Each study visit will include collection of blood samples for batch testing of aminotransferase, serum acetaminophen and protein adducts. No interventions are planned.
Conditions
Timeline
- Start date
- 2009-11-01
- Primary completion
- 2011-03-01
- Completion
- 2011-03-01
- First posted
- 2009-11-30
- Last updated
- 2012-08-08
Locations
2 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT01021410. Inclusion in this directory is not an endorsement.