NCT01021176

Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell

A Single Dose Pilot Study to Evaluate the Safety and Dose-Response of Smell to Intranasal Diltiazem

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.

Detailed description

You will fast on your first visit. Complete questionnaire about taste and smell to insure you don't have a cold or anything that would interfere with sense of smell. Your nose will be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or a placebo. Your sense of smell will be tested at different time points.

Conditions

• Food Intake

Interventions

Type	Name	Description
OTHER	Placebo spray	0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray yet no drug will be administered
DRUG	Diltiazem	0, 30, 60, 90, 120, 180, and 240 minutes following the nasal spray Three Dilutions would be 5.5, 6.0 and 6.3 and the fourth at the filp of a coin randomly diluted.

Timeline

• Start date: 2009-10-01
• Primary completion: 2009-11-01
• Completion: 2009-11-01
• First posted: 2009-11-26
• Last updated: 2015-12-18

Locations

1 site across 1 country: United States