NCT01020903

Aprepitant for Post-operative Nausea

Aprepitant vs. Placebo for the Prevention of Postoperative Nausea and Vomiting: a Randomized, Double-blind Study in Patients Undergoing Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Northwell Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Anesthesia, especially for laparoscopic surgery, can cause post-operative nausea and vomiting. Most patients are given two drugs, decadron and ondansetron, to try to minimize this. This study is to determine if a new drug, aprepitant, would add any benefit in terms of post-op nausea prevention. All laparoscopic cholecystectomy study patients will receive decadron and ondansetron. Half the patients will receive aprepitant in addition. The other half will receive placebo. The study will be randomized and double-blind.

Conditions

• Postoperative Nausea

Interventions

Type	Name	Description
PROCEDURE	Aprepitant	40 mg po pre-op
DRUG	Placebo	Orally, pre-op

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-11-01
• Completion: 2010-11-01
• First posted: 2009-11-26
• Last updated: 2023-11-22
• Results posted: 2015-06-04

Locations

1 site across 1 country: United States