NCT01018108

Visualization of the Effect of Acupuncture on Brain Serotonin in Breast Cancer Survivors

Effect of Acupuncture on Brain Serotonin Among Breast Cancer Survivors

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 7 (estimated)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: New imaging procedures, such as single photon emission computed tomography, may help in learning how acupuncture affects serotonin levels in the brain of breast cancer survivors. PURPOSE: This phase I trial is studying the best way to visualize the effect of acupuncture on brain serotonin in breast cancer survivors.

Detailed description

Detailed Description OBJECTIVES: I. To determine the feasibility of using \[123-I\] ADAM Serotonin transporter (SERT) binding as a putative biomarker to visualize the mechanism of effects of acupuncture for hot flashes involving serotonin. OUTLINE: Patients undergo acupuncture twice weekly for 2 weeks and then once weekly for 6 weeks. Patients undergo single photon emission computed tomography imaging with iodine 123-I ADAM before and after completion of acupuncture. After completion of study treatment, patients are followed for 4 weeks.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
PROCEDURE	Single Photon Emission Computed Tomography	Undergo single photon emission computed tomographt imaging
PROCEDURE	Acupuncture Therapy	Undergo acupuncture
OTHER	Questionnaire Administration	Ancillary study
OTHER	Laboratory Biomarker Analysis	Correlative Study

Timeline

• Start date: 2009-03-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2009-11-23
• Last updated: 2016-01-26

Locations

1 site across 1 country: United States