NCT01016145

Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm

Identifying Predictors of Response in 12 Weeks of Treatment With Antipsychotics Using a Treatment Algorithm for Schizophrenia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 126 (estimated)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.

Conditions

• Schizophrenia or Schizoaffective Disorder

Interventions

Type	Name	Description
DRUG	Antipsychotics	Quetiapine 25-800 mg; ziprasidone 80-160 mg; olanzapine 5-20mg; risperidone 2-8 mg; aripiprazole 15-30 mg
DRUG	Antipsychotics	Haloperidol 2,5-10 mg; chlorpromazine 25-600 mg.

Timeline

• Start date: 2009-04-01
• Primary completion: 2010-06-01
• Completion: 2010-07-01
• First posted: 2009-11-19
• Last updated: 2009-11-19

Locations

1 site across 1 country: Brazil