NCT01015794

Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Bayside Health · Other Government
• Sex: Male
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response to the non-specific beta adrenergic receptor (AR) agonist ephedrine. The investigators hypothesise that this pharmacological adrenergic stimulus will result in activation of BAT in these participants, and that this activation will be reduced in obese patients. This study will provide important preliminary information with respect to allowing the investigators to progress with longer trials with specific beta 3 AR agonists.

Conditions

• Obesity

Interventions

Type	Name	Description
DRUG	ephedrine hydrochloride	single oral dose, 1mg/kg body weight
DRUG	ephedrine hydrochloride	single dose of 1 mg/kg body weight

Timeline

• Start date: 2009-12-01
• Primary completion: 2012-12-01
• First posted: 2009-11-18
• Last updated: 2013-02-15

Locations

1 site across 1 country: Australia