NCT01012232

Local Anesthetic in Total Knee Arthroplasty (TKA): Volume Versus Concentration

The Volume-concentration Relationship of Analgesic Efficacy With Intra-capsular Local Anesthetic in Total Knee Arthroplasty: a Randomized, Double-blind, Cross-over Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Lundbeck Foundation · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

In a randomized, double-blind, cross-over trial, 48 patients scheduled for total knee arthroplasty with placement of an intracapsular catheter will be randomized to receive bolus injection of ropivacaine in high volume/low concentration (20 ml, 5 mg/mL) or low volume/high concentration (10 mL, 10 mg/mL) 6 and 24 hours postoperatively, and pain will be assessed at rest and with mobilization for 2 hours after injections.

Conditions

• Postoperative Pain
• Analgesic Efficacy

Interventions

Type	Name	Description
DRUG	20 mL ropivacaine 5 mg/mL
DRUG	10 mL ropivacaine 10 mg/mL

Timeline

• Start date: 2009-06-01
• Primary completion: 2009-10-01
• Completion: 2009-10-01
• First posted: 2009-11-11
• Last updated: 2009-11-11

Locations

1 site across 1 country: Denmark