Trials / Unknown
UnknownNCT01009710
Measured Hypocretin Levels and Recovery After Hip Surgery
Preoperative Cerebrospinal Fluid (CSF) Levels of Hypocretin and Recovery After Hip Surgery With Combined Spinal and General Anesthesia
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Stanford University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
Conditions
Timeline
- Start date
- 2009-07-01
- Primary completion
- 2013-12-01
- Completion
- 2018-12-01
- First posted
- 2009-11-09
- Last updated
- 2017-01-18
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01009710. Inclusion in this directory is not an endorsement.