NCT01008631

The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy Volunteers

The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The pharmacokinetics of sodium thiosulfate in humans with different degrees of renal failure and in healthy volunteers will be after two single shot applications.

Detailed description

Two single shot applications of i.v. sodium thiosulfate will be given to dialysis patients. One application will be given immediately before a dialysis session and the second dose will be given after the consecutive dialysis session. In healthy volunteers sodium thiosulfate will be given only once. In both groups, dialysis patients and healthy volunteers, blood and urinary/dialysate samples will be collected at defined time points.

Conditions

• Renal Failure

Interventions

Type	Name	Description
DRUG	Sodium thiosulfate	6g of Sodium Thiosulfate are applicated in a short infusion over a time of 5 min

Timeline

• Start date: 2009-09-01
• Primary completion: 2010-08-01
• Completion: 2010-08-01
• First posted: 2009-11-06
• Last updated: 2011-10-13

Locations

1 site across 1 country: Switzerland