NCT01008540

Prospective Multicentric Study of Cytomegalovirus Resistance in Transplant Patients and Bone Marrow Recipients

Cytomegalovirus Resistance in Transplant Patients and Bone Marrow Recipients in the Prophylaxis Era, a French Multicentric Cohort Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 800 (estimated)
• Sponsor: University Hospital, Limoges · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators aim is to determine the incidence of cytomegalovirus resistance to antivirals in a cohort study. The patients are included at their first CMV active infection and are followed during two years thereafter. When criteria for suspected resistance are meet, blood and urine samples are collected for virus isolation and further resistance phenotype, and for resistance genotype determination. Results are compared with baseline samples. Clinical information such as treatment, immunosuppressive regimen and clinical evolution will be collected. Through this study, the investigators aim to organize a national network for the detection and identification of CMV resistant strains that will be useful when new therapeutics will be available.

Conditions

• Cytomegalovirus

Interventions

Type	Name	Description
BIOLOGICAL	depistage	Virus isolation from urine, blood, or any suitable sample in case of CMV disease Resistance phenotype to antivirals UL97 and UL54 genes sequencing from blood, urines or any suitable samples for resistance mutations detection and polymorphism study

Timeline

• Start date: 2006-08-01
• Primary completion: 2010-12-01
• Completion: 2012-06-01
• First posted: 2009-11-06
• Last updated: 2025-07-20

Locations

33 sites across 1 country: France