NCT01005485

Molecular and Morphologic Characterization of Circulating Endothelial Cells

Comprehensive Molecular and Morphologic Characterization of Circulating Endothelial Cells

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 664 (actual)
• Sponsor: Scripps Translational Science Institute · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The primary hypothesis of this study is that circulating endothelial cells (CECs) harbor key genetic and structural characteristics predisposing individuals to acute atherosclerotic plaque rupture and heart attack.

Detailed description

Endothelial injury and inflammation are pivotal underlying processes that put patients at risk for catastrophic vascular events including acute myocardial infarction (heart attack) and stroke. We seek to accelerate scientific discovery through clinically meaningful, innovative translational research, and are collaborating in a trans-disciplinary effort to define the DNA sequence of CECs and that of germ line DNA, along with RNA sequencing, mRNA expression profiling, and ultrastructural characterization of CECs in order to better understand the mechanisms leading to acute arterial plaque rupture and embolization of arterial endothelial cells in patients with acute myocardial infarction. This will enable us to create a molecular fingerprint that could identify and preempt individuals from suffering from such debilitating vascular conditions.

Conditions

• Acute Myocardial Infarction

Timeline

• Start date: 2010-01-01
• Primary completion: 2017-04-01
• Completion: 2025-12-01
• First posted: 2009-11-02
• Last updated: 2025-01-17

Locations

1 site across 1 country: United States