NCT00999089

Arrested Versus Beating Heart Techniques in Coronary Revascularisation

Arrested Versus Beating Heart Techniques in Coronary Revascularisation: Randomized Clinical Trial in Unselected Patients

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 616 (actual)
• Sponsor: Martin-Luther-Universität Halle-Wittenberg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The individual contribution of the specific injuring mechanisms surgical trauma, extracorporeal circulation, and ischemia/reperfusion to clinical outcome in coronary revascularisation remains to be elucidated. The effect of these factors is analyzed in this randomized clinical trial by comparing the 3 surgical approaches: Conventional Coronary Artery Bypass Grafting (CCAB), with extracorporeal circulation and cardioplegic arrest; Off-Pump Coronary Artery Bypass Grafting (OPCAB), avoids extracorporeal circulation and global myocardial ischemia; and Pump-Assisted Coronary Artery Bypass Grafting (PACAB), with an unloaded and beating heart. The hypothesis addressed by the study is that the surgical invasiveness increases in the order: OPCAB, PACAB, CCAB.

Conditions

• Coronary Artery Bypass Grafting

Interventions

Type	Name	Description
PROCEDURE	Conventional Coronary Artery Bypass	Coronary artery bypass grafting with extracorporeal circulation and cardioplegic arrest
PROCEDURE	Off-Pump Coronary Artery Bypass	Coronary artery bypass grafting without extracorporeal circulation or global myocardial ischemia
PROCEDURE	Pump-Assisted Coronary Artery Bypass	Coronary artery bypass grafting with a beating but unloaded heart by using extracorporeal circulation

Timeline

• Start date: 2003-01-01
• Primary completion: 2006-09-01
• Completion: 2010-09-01
• First posted: 2009-10-21
• Last updated: 2009-10-21

Locations

2 sites across 1 country: Germany