NCT00996229

Effects of Dietary Interventions on the Aging Brain

Phase IV Interventional Study: Effects of Dietary Interventions on Brain Functions in Healthy Elderly People

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.

Detailed description

The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects. Referring to animal data, empirical studies, and pilot human trials, a healthy diet rich in unsaturated fatty acids and low in calories should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in healthy elderly subjects (50-80 years old) during a short term diet.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	Caloric restriction	20-30% CR for 6 months
DIETARY_SUPPLEMENT	Omega-3 (fish oil capsules)	2g/day DHA/EPA capsules for 6 months
DIETARY_SUPPLEMENT	Placebo	Daily corn oil capsules for 6 months
DIETARY_SUPPLEMENT	Resveratrol	daily resveratrol for 6 months

Timeline

• Start date: 2009-11-01
• Primary completion: 2013-12-01
• Completion: 2014-02-01
• First posted: 2009-10-16
• Last updated: 2013-04-19

Locations

1 site across 1 country: Germany