NCT00993902

Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 228 (actual)
• Sponsor: Baskent University · Academic / Other
• Sex: Female
• Age: 20 Years – 37 Years
• Healthy volunteers: Accepted

Summary

Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (\>16mm).

Detailed description

Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI. Inclusion criteria: 1. Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit. 2. Female age \<37 years old. 3. Baseline FSH \<12 mIU/L 4. Total antral follicle count\>6 5. During the first three cycles of COH+IUI 6. Minimum 2 follicles \>16 mm at the day of HCG. Primary outcome: Ongoing pregnancy rates Secondary outcomes: The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	Intrauterine insemination (single)	Single IUI after 36-38 hours of HCG
PROCEDURE	Double intrauterine insemination	Double insemination after 18 and 40 hours of HCG administration.

Timeline

• Start date: 2008-05-01
• Primary completion: 2009-05-01
• Completion: 2009-07-01
• First posted: 2009-10-14
• Last updated: 2009-10-14

Locations

1 site across 1 country: Turkey (Türkiye)