NCT00993291

Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)

Effect of Frequency Change in Bilateral Subthalamic Nucleus (STN)-DBS on Gait Function in PD

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking. The investigators' hypothesis is: 1. Stimulation at 60 Hertz (Hz) is associated with improved gait with increased stride length and faster time on the Stand walk sit test. 2. There is no worsening of the Unified Parkinson's Disease Rating Scale (UPDRS) at 60 Hz.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
PROCEDURE	Frequency change to 60 Hz	60 Hz stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.
PROCEDURE	Frequency change to 130 Hz	130 Hz Stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.

Timeline

• Start date: 2009-11-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2009-10-12
• Last updated: 2012-01-27
• Results posted: 2012-01-27

Locations

1 site across 1 country: United States