NCT00991575

Long Term Vascular Changes in Type 1 Diabetes

Long Term Vascular Changes in Type 1 Diabetes, Clinical Aspects and Biological Markers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 33 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to investigate progression of late complications of diabetes during the last ten years in a well characterized cohort of type 1 diabetes with a long duration of the disease, and to define factors responsible for the progression of late complications.

Detailed description

Despite intensively research in the field of hyperglycaemia and coronary heart disease in type 1 diabetes it is still not known in detail how hyperglycaemia leads to damage of the vessels. The aims of the present proposal are therefore two-fold: 1. To study in detail the progression of atherosclerosis (and micro vascular complications) in a well characterized cohort of type 1 diabetes with a long duration of the disease. This project will be a continuation of the Oslo study, a cohort started in 1982, with the last follow-up study in 1999/2000. 2. To define factors responsible for the progression of coronary heart disease (and micro vascular complications) in this cohort.

Conditions

• Diabetes Mellitus, Type 1
• Complications
• Coronary Heart Disease

Timeline

• Start date: 2009-04-01
• Primary completion: 2010-05-20
• Completion: 2010-06-20
• First posted: 2009-10-08
• Last updated: 2023-05-08

Locations

1 site across 1 country: Norway