NCT00977262

Postprandial Inflammation and Fatty Acids

Effects of Fatty Acids on Postprandial Inflammatory Response of Healthy Obese and Type 2 Diabetic Obese Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Wageningen University · Academic / Other
• Sex: Male
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on peripheral blood mononuclear cells (PBMC) whole genome expression of obese and type 2 diabetic obese subjects.

Detailed description

Consumption of high-fat diets can lead to postprandial dyslipidemia, impairment of endothelial function, activation of immune cells and changes in gene expression profiles of immune cells such as peripheral blood mononuclear cells (PBMC). Recently it was shown that postprandial gene expression profiles of PBMC and plasma triglyceride (TG) and free fatty acid (FFA) responses are dependent on the type of dietary fat consumed (i.e. saturated, monounsaturated and polyunsaturated). Since obese and diabetic subjects usually are in a pro-inflammatory state and have dyslipidemia and endothelial dysfunction we are interested in the effect of different fatty acids in a high load on the PBMC gene expression profiles, plasma cytokine profiles and endothelial function of these subjects.

Conditions

• Cardiovascular Disease
• Diabetes Type 2
• Obesity

Interventions

Type	Name	Description
OTHER	High saturated fat shake	milkshake containing 95 gram of fat, high percentage of saturated fat
OTHER	High monounsaturated fat shake	milkshake containing 95 gram of fat, high percentage of monounsaturated fat
OTHER	High polyunsaturated fat shake	milkshake containing 95 gram of fat, high percentage polyunsaturated fat

Timeline

• Start date: 2009-10-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2009-09-15
• Last updated: 2010-04-21

Locations

2 sites across 1 country: Netherlands