NCT00974922

Vitamin D Deficiency in Patients With Hypertension

Vitamin D Deficiency, Renin Inhibitor Response, and Vitamin D Supplementation in Patients With Hypertension

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: UConn Health · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the effects of Vitamin D replacement and the effects of an approved medication for hypertension, aliskiren (Tekturna), in patients with high blood pressure who have low levels of vitamin D in their blood. The study will compare the effects of vitamin D or aliskiren alone and in combination on 24-hour blood pressure and biochemical parameters.

Detailed description

This study will assess whether aliskiren will lower clinic blood pressure and 24-hour blood pressure in patients with hypertension and vitamin D deficiency. Additionally, this study will further explore the potential additional effects of adding vitamin D to aliskiren in this patient population.

Conditions

• Vitamin D Deficiency
• Hypertension

Interventions

Type	Name	Description
DRUG	Aliskiren	150 mg once daily for 2 weeks, then titrated to 300 mg once daily for 4 weeks
DIETARY_SUPPLEMENT	Cholecalciferol	3000 I.U. once daily for 6 weeks
DIETARY_SUPPLEMENT	Placebo	Placebo for two weeks

Timeline

• Start date: 2009-08-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2009-09-11
• Last updated: 2018-03-09
• Results posted: 2018-03-09

Locations

1 site across 1 country: United States