NCT00973206

Factors Influencing Cardiovascular Prognosis

Factors Influencing Cardiovascular Prognosis in Hypertensive Patients (Pythia Study)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 5,000 (estimated)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to identify risks for cardiovascular events in a follow up period of 10 years.

Detailed description

Inclusion criteria * Age \> 50 years volunteers (2 towns of 15000 residents one in the north and one in the south of Greece) * End points * 5-10 years cardiovascular morbidity and mortality Measurements at baseline * Anthropometrics * Age (M\>55 years; W\>65 years) * Weight-height- BMI * Abdominal obesity (Waist circumference\>102 cm(M), \>88cm (W) Family history * Family history of premature CV disease (M at age\<55 years; W at age\<65 years) History * Smoking * Diabetes Mellitus, * Established Heart disease: myocardial infarction; angina; coronary revascularization; heart failure * Established renal disease \[diabetic nephropathy; renal impairment (serum creatinine M\>133, W\>124 mmol/l); proteinuria (\> 300 mg/24 h)\] * Cerebrovascular disease: ischaemic stroke; cerebral haemorrhage; transient ischaemic attack * Peripheral artery disease * Advanced retinopathy: haemorrhages or exudates, papilloedema * Treatment Measurements * Measurements Blood pressure * Clinic BP * 24h ABPM * Home BP Heart * Electrocardiographic LVH * Echocardiographic LVH Vessels * Carotid wall thickening or plaque * Carotid-femoral pulse wave velocity * Ankle/brachial BP index Lipids or other risk factors * Total cholesterol, Tg, HDL, LDL * Plasma creatinine, estimated glomerular filtration rate * Fasting plasma glucose or postload plasma glucose * Microalbuminuria and albumin-creatinine ratio * Glucose tolerance test * Follow up each 3 year with all the above measurements

Conditions

• Cardiovascular Mortality

Timeline

• Start date: 2017-01-01
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2009-09-09
• Last updated: 2014-06-25