NCT00968578

Effects of Methylprednisolone After Total Knee Arthroplasty

Effects of Pre-operative Methylprednisolone (125mg iv) After Total Knee Arthroplasty: A Prospective, Randomized, Double-blind, Placebo-controlled Trail

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty. The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.

Detailed description

In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total knee arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after knee arthroplasty.

Conditions

• Postoperative Pain
• Postoperative Nausea and Vomiting
• Sleeping Quality
• Fatigue
• Inflammatory Response

Interventions

Type	Name	Description
DRUG	Methylprednisolone	Methylprednisolone 125 mg iv pre-operatively
DRUG	Placebo	Saline iv pre-operatively in equivalent volume (placebo)

Timeline

• Start date: 2009-08-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2009-08-31
• Last updated: 2012-09-26

Locations

1 site across 1 country: Denmark