NCT00966485

Dose-related Effect of Aspirin on Laboratory-defined Acetylsalicylic Acid Resistance and Clinical Outcome After Coronary Stenting

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Shiraz University of Medical Sciences · Academic / Other
• Sex: All
• Age: 40 Years – 67 Years
• Healthy volunteers: Not accepted

Summary

The investigators prospectively studied the effect of aspirin on platelet function in 106 stable outpatients 6 months after successful percutaneous coronary angioplasty. Participants were randomized in a double-blind, double-crossover study (80 or 500 mg per day for 6 months).T

Detailed description

Background: Acetylsalicylic acid (aspirin) is widely used in the secondary prevention of coronary artery disease. There is controversy regarding the prevalence of aspirin resistance in patients with coronary artery disease and the effect of dose on resistance. Our primary aims were to determine the degree of platelet responsiveness to aspirin, and to study the influence of dose on platelet inhibition and clinical outcomes after coronary stenting.

Conditions

• Coronary Stenting

Interventions

Type	Name	Description
DRUG	80 mg ASA dosing
DRUG	500 mg ASA dosing

Timeline

• Start date: 2006-10-01
• Primary completion: 2008-10-01
• Completion: 2008-10-01
• First posted: 2009-08-27
• Last updated: 2009-08-27

Locations

1 site across 1 country: Iran