NCT00966355

Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding

RCT for the Effect of Early Administration of Vasoactive Substances When Combined With Endoscopic Treatment in Acute Gastro-esophageal Variceal Bleeds: Comparisons Among Terlipressin, Somatostatin, and Octreotide

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,034 (actual)
• Sponsor: Korea University · Academic / Other
• Sex: All
• Age: 16 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

Detailed description

In patients who are suspected to have variceal bleedings, pharmacologic therapy with vasoactive drugs such as terlipressin, somatostatin, and octreotide is recommended as soon as possible, even before endoscopy. However, it is still unclear whether the efficacies of these drugs are same or not. This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

Conditions

• Variceal Bleeding, Cirrhosis

Interventions

Type	Name	Description
DRUG	Terlipressin	loading with 2 mg IV, and then 1 mg IV every 4 hours for 5 days
DRUG	Somatostatin	loading with 250 microgram IV, and then 250 microgram/hour continuous IV for 5 days
DRUG	Octreotide	loading with 50 microgram IV, and then 25 microgram/hour continuous IV for 5 days

Timeline

• Start date: 2006-09-01
• Primary completion: 2010-05-01
• Completion: 2010-05-01
• First posted: 2009-08-26
• Last updated: 2018-03-19
• Results posted: 2018-03-19

Locations

1 site across 1 country: South Korea