NCT00966082

EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment

RCT Comparing the Efficacies of Endoscopic Band Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding in Patients With Previous Endoscopic Variceal Treatment

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Korea University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.

Detailed description

Both propranolol and endoscopic band ligation (EBL) are effective for prevention of variceal rebleeding. Recently several studies compared the efficacy of EBL alone and with a combination of propranolol and EBL. However, the results of recent studies showed discrepancy. In addition, most of all recent studies included patients without previous endoscopic treatment for varices. This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.

Conditions

• Cirrhosis
• Variceal Bleeding

Interventions

Type	Name	Description
PROCEDURE	endoscopic band ligation	Perform EBL until esophageal varices are eradicated, and then follow-up endoscopy with 3-6 months interval
PROCEDURE	endoscopic band ligation+Propranolol	Perform EBL same as EBL group. In addition, take propranolol to reduce 25% in HR or HR ≤55/min

Timeline

• Start date: 2008-08-01
• Primary completion: 2019-07-01
• Completion: 2021-07-01
• First posted: 2009-08-26
• Last updated: 2017-08-22

Locations

1 site across 1 country: South Korea