NCT00966056

Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae

Comparative Study of Mitomycin C and Internal Nasal Septal Splint in the Treatment of Nasal Synechiae

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Karnataka Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.

Detailed description

Nasal synechiae is an important cause for the failure of many a nasal surgery. Septal splints have been widely used for the treatment of nasal synechiae, but are associated significant morbidity until removal. To the best of our knowledge there are no studies in literature comparing Mitomycin C with septal splints as an atraumatic alternative in the treatment of nasal synechiae. This is a preliminary study taken up to evaluate the therapeutic efficacy of Mitomycin C in the treatment of nasal synechiae.

Conditions

• Nasal Synechiae
• Adhesions of Nasal Cavity
• Nasal Adhesions
• Tissue Adhesions

Interventions

Type	Name	Description
DRUG	Mitomycin C	Cotton wick soaked with 1mg/ml of mitomycin c placed for 2 minutes between the raw surfaces after synechiolysis with surgical blade no.15
DEVICE	Teflon nasal septal splint	Teflon internal nasal septal splint placed between the raw surfaces and secured at the anterior end of septum with catgut 3-0 sutures, following synechiolysis with surgical blade no.15. Splint removed at the end of one week

Timeline

• Start date: 2007-10-01
• Primary completion: 2009-02-01
• Completion: 2009-09-01
• First posted: 2009-08-26
• Last updated: 2011-07-08

Locations

1 site across 1 country: India