Trials / Completed
CompletedNCT00965627
Biology of Thymic Tumors
Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 134 (actual)
- Sponsor
- Istituto Clinico Humanitas · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
Detailed description
The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.
Conditions
Timeline
- Start date
- 2008-06-01
- Primary completion
- 2008-08-01
- Completion
- 2009-08-01
- First posted
- 2009-08-25
- Last updated
- 2009-08-28
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT00965627. Inclusion in this directory is not an endorsement.