NCT00964769

Study of Evaluation Indexes for Antibody Production in Sera After Immunization

A Study of Evaluation Indexes for Antibody Production in Sera After Immunization

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Ewha Womans University · Academic / Other
• Sex: All
• Age: 2 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate analytical methods such as ELISA and OPKA that measure the activity of vaccine-induced pneumococcal antibodies. After validation of ELISA and OPKA, pneumococcal antibodies were measured by ELISA and OPKA in paired samples before and after immunization (pneumococcal PS vaccine) in children, adults and elderly.

Detailed description

To evaluate the immune response to the pneumococcal polysaccharide vaccine in the elderly, samples from children, young adults and elderly were obtained before and one month after vaccination. The quantitative and qualitative response to the vaccine were measured by the ELISA and opsonophagocytic killing assay for eight vaccine type serotypes (4, 6B, 9V, 14, 18C, 19A, 19F, 23F) and one vaccine-related serotype (6A).

Conditions

• Aged

Interventions

Type	Name	Description
BIOLOGICAL	pneumococcal polysaccharide vaccine	single intramuscular injection of 0.5 ml Pneumo23® (Sanofi-Aventis, Lyon France)

Timeline

• Start date: 2005-04-01
• Primary completion: 2005-05-01
• Completion: 2005-06-01
• First posted: 2009-08-25
• Last updated: 2009-08-25

Locations

1 site across 1 country: South Korea