NCT00962962

Exercise Dose-Response Effects in Prediabetes

Exercise Dose-Response Effects in Prediabetes: Responses and Mechanisms

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 288 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to evaluate the effects of different amounts and intensities of aerobic exercise training programs, with and without weight loss, in people who are at risk for diabetes. An additional purpose of the study is to evaluate the factors in the blood and in exercising muscles that contribute to the improvement in those risk factors. This information will be used to improve exercise training guidelines for improving cardiovascular and metabolic health in people with abnormal fasting glucose, also known as prediabetes.

Detailed description

729 subjects were consented, 288 participants were randomized.

Conditions

• Pre-Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Aerobic Exercise	Aerobic exercise at 50% peak oxygen use/consumption expending approximately 1,000 calories per week equaling approximately 10 miles per week OR 2.5-3.5 hours per week
BEHAVIORAL	Aerobic Exercise	Aerobic exercise at 50% peak oxygen use/consumption expending approximately 1,600 calories per week equaling approximately 16 miles per week OR 4-6 hours per week
BEHAVIORAL	Aerobic Exercise	Aerobic exercise at 75% peak oxygen use/consumption expending approximately 1,600 calories per week equaling approximately 16 miles per week OR 2-3 hours per week
BEHAVIORAL	Exercise and Diet	* Exercise - 150 minutes per week (30 minutes / 5 days per week) of aerobic exercise at 50% peak oxygen use/consumption equaling approximately 10 miles per week * Diet - The Clinical Lifestyle Intervention sessions will provide training on needed skills (e.g., calorie counting, portion size estimation) as well as motivation and support in a group counseling setting designed to achieve a weight loss goal of 5 to 7% of baseline body weight.

Timeline

• Start date: 2009-07-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2009-08-20
• Last updated: 2014-07-15

Locations

1 site across 1 country: United States