NCT00961233

Topical Budesonide Treatment for Eosinophilic Esophagitis (EoE)

Topical Budesonide Treatment for Eosinophilic Esophagitis (EoE): Esophageal Medication Distribution, Treatment Response, and Effect on the Adrenal Axis.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to conduct a clinical trial of two formulations of budesonide (nebulized/swallowed versus viscous/swallowed) in patients with EoE to determine if medication contact time and distribution in the esophagus relates to treatment response. The investigators will also determine if there is systemic absorption of these topical steroids. The investigators hypothesize that tissue and symptom response will correlate with esophageal medication contact time and distribution, and that significant systemic absorption will not be seen.

Conditions

• Eosinophilic Esophagitis

Interventions

Type	Name	Description
DRUG	inhaled/swallowed budesonide	medication will be nebulized and then swallowed
DRUG	viscous/swallowed budesonide	viscous suspension of budesonide will be swallowed

Timeline

• Start date: 2009-10-01
• Primary completion: 2011-08-01
• Completion: 2011-11-01
• First posted: 2009-08-18
• Last updated: 2012-11-06
• Results posted: 2012-11-05

Locations

1 site across 1 country: United States