NCT00959166

To Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-Infection

A Prospective Case-control Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-infection - a PET Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 81 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: Male
• Age: 25 Years
• Healthy volunteers: Accepted

Summary

This study plans to evaluate what happens to the brain in patients with HIV and early hepatitis C. The investigators will be comparing 3 groups of individuals: * Group 1: Individuals with HIV infection and acute (early) hepatitis C infection * Group 2: Individuals with HIV infection * Group 3: Healthy volunteers

Detailed description

Subtle changes to the brain, which doctors find difficult to detect through conversation or examination, may occur in patients with HIV and/or hepatitis C infection. It is not currently known whether the brain is affected in early (or acute) hepatitis C. Individuals wishing to take part will complete a series of tests assessing different aspects of their brain including: * 2 brain scans using different technology: * Magnetic resonance imaging (MRI) brain scan with spectroscopy * CT PET brain scan * A computer game test which measures brain function * 2 short questionnaires Results of these tests will be analyzed and compared between 3 groups.

Conditions

• Acute Hepatitis C
• HIV
• HIV Infections

Interventions

Type	Name	Description
OTHER	PET scan	PET brain scan

Timeline

• Start date: 2009-06-01
• Primary completion: 2011-06-01
• Completion: 2011-09-01
• First posted: 2009-08-14
• Last updated: 2019-10-22
• Results posted: 2019-10-22

Locations

1 site across 1 country: United Kingdom