Trials / Completed
CompletedNCT00954655
Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001
Genetic Risk Factors for Gastrointestinal Stromal Tumors (GIST)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 1 (actual)
- Sponsor
- Alliance for Clinical Trials in Oncology · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor samples in patients undergoing treatment for gastrointestinal stromal tumors on clinical trial ACOSOG-Z9001.
Detailed description
OBJECTIVES: Primary * To examine polymorphisms in selected genes involved in the detoxifying/metabolizing and DNA repair pathways in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from patients with gastrointestinal tumors (GIST) undergoing treatment on clinical trial ACOSOG-Z9001. Secondary * To examine approximately 758 polymorphisms among candidate genes involved in detoxification/metabolism, cell cycle control, and DNA damage/repair in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from GIST patients for hypothesis generation. (exploratory) * To conduct an exploratory analysis of the polymorphism distribution in these patients. (exploratory) * To examine the association between the above polymorphisms and major toxicity (Grade 3/4) of adjuvant imatinib mesylate. (exploratory) OUTLINE: Tumor samples are used for polymorphism and mutation analysis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | mutation analysis | |
| GENETIC | polymorphism analysis | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2008-12-01
- Primary completion
- 2013-04-01
- Completion
- 2013-04-01
- First posted
- 2009-08-07
- Last updated
- 2019-01-30
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00954655. Inclusion in this directory is not an endorsement.