NCT00948545

Autonomic Nervous System Function Following Bariatric Surgery

Autonomic Nervous System Function and Novel Determinants of Glucose Homeostasis Following Bariatric Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37 (actual)
• Sponsor: Christiana Care Health Services · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

In the proposed study, the investigators will explore three specific aims. First, the investigators will examine cross-sectionally the association of obesity on sympathetic, parasympathetic, and sympathetic/ parasympathetic nerve fiber balance. In addition, the investigators will determine the relationship of the ANS and osteocalcin. Osteocalcin will be measured before and after a mixed meal tolerance test. In the second specific aim, the investigators will prospectively follow-up these individuals (n=30) following bariatric surgery. The effect of weight loss on measures of the ANS and osteocalcin will be examined 6 months following surgery with participants serving as their own control, pre- and post-surgical intervention. Thirdly, the investigators will address whether the effect of weight loss on the ANS and osteocalcin differ between those who had a history of diabetes at baseline versus those with no history of diabetes.

Conditions

• Bariatric Surgery

Interventions

Type	Name	Description
OTHER	Observational study - there is no intervention	Observational study - there is no intervention

Timeline

• Start date: 2009-07-01
• Primary completion: 2011-06-01
• Completion: 2012-04-01
• First posted: 2009-07-29
• Last updated: 2012-11-07

Locations

1 site across 1 country: United States