NCT00946166

Impact of Statins on Cytokine Expression in Pneumonia

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: The University of Texas Health Science Center at San Antonio · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators are conducting a study to determine the effects of a cholesterol-lowering medication, called simvastatin on pneumonia. People in the study will be in the hospital because they have pneumonia. The people will also have a medical condition like heart disease, diabetes, stroke or high cholesterol for which cholesterol-lowering medication has been shown to prevent future disease and/or death but are not taking a cholesterol-lowering medication when they go to the hospital. Some people will get treated with antibiotics only and other people will get antibiotics and simvastatin while they are in the hospital. The study will compare the effects the combination of simvastatin and antibiotics has on people with pneumonia to treatment with antibiotics alone.

Conditions

• Community Acquired Pneumonia
• Cardiovascular Risk Factors

Interventions

Type	Name	Description
DRUG	simvastatin	40 mg daily in the evening for a maximum of 14 days
DRUG	Placebo	Simvastatin-like placebo administered daily in the evening for a maximum of 14 days

Timeline

• Start date: 2009-07-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2009-07-24
• Last updated: 2015-04-22

Locations

1 site across 1 country: United States