Trials / Terminated
TerminatedNCT00945126
Allogeneic Stem Cell Transplantation in Pediatric Patients With Malignant and Non-malignant High-risk Diseases
Allogeneic Stem Cell Transplantation With CD3/CD19 Depleted Stem Cells of Related or Unrelated Haploidentical Donors in Pediatric Patients With Malignant and Non-malignant Diseases
- Status
- Terminated
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 68 (actual)
- Sponsor
- Johann Wolfgang Goethe University Hospital · Academic / Other
- Sex
- All
- Age
- 30 Years
- Healthy volunteers
- Not accepted
Summary
The aim of the study is to investigate the feasibility and toxicity of allogeneic haploidentical or unrelated transplantation with CD3/CD19 depleted stem cells associated with a reduced or a standard conditioning regimen in pediatric patients with malignant and non-malignant high-risk diseases, for whom allogeneic stem cell transplantation represents the only possible therapy option and no human leukocyte antigen (HLA) compatible related donors are available.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Hematopoietic stem cell product from haploidentical or unrelated donor CD3/CD19 depleted with CliniMACS | The aim is to transplant 7x106 CD34+/kg of recipient body weight. |
Timeline
- Start date
- 2006-12-01
- Primary completion
- 2017-08-01
- Completion
- 2017-08-01
- First posted
- 2009-07-23
- Last updated
- 2018-08-15
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT00945126. Inclusion in this directory is not an endorsement.